The Duffy lab is interested in the viral components of air, water and terrestrial environments, and how viral evolution shapes global ecology. One of the main foci of the lab is single-stranded DNA viruses, which are now recognized as ubiquitous on all continents and in bodies of water, but for most sequences they have no sense of their definitive hosts. While most of their work is computational, they maintain an active experimental evolution lab with RNA and ssDNA bacteriophages.